The 11‐zinc finger protein CCCTC‐binding factor (CTCF) is a highly conserved protein, involved in imprinting, long‐range chromatin interactions and transcription. To investigate its function in vivo, ...

Although centriolar satellites are increasingly being recognized as important subcellular structures that are tightly linked to centrosome functions, human disease, and cell differentiation, little is ...

These findings highlight the dual roles of antioxidants in cancer. Their impact depends on cancer type, stage, and genetic ...

On the occasion of its 40th anniversary, The EMBO Journal has launched the Catalysts program with the aim to give the next generation of group leaders a stronger voice in all aspects of publishing at ...

Cas3 is a single‐stranded DNA nuclease and ATP‐dependent helicase in the CRISPR/Cas immune system ...

The CRISPR ‐associated protein Cas9 is widely used for genome editing because it cleaves target DNA through the assistance of a single‐guide RNA (sg RNA). Structural studies have revealed the ...

In eukaryotes, enzymes of different subcellular compartments participate in the assembly of membrane lipids. As a consequence, interorganelle lipid transfer is extensive in growing cells. A prominent ...

Glutaconyl‐CoA decarboxylase is a biotin‐dependent ion pump whereby the free energy of the glutaconyl‐CoA decarboxylation to crotonyl‐CoA drives the electrogenic transport of sodium ions from the ...

In mammals, maintenance of energy and nutrient homeostasis during food deprivation is accomplished through an increase in mitochondrial fatty acid oxidation in peripheral tissues. An important ...

The forkhead transcription factors are winged helical proteins first known for their role in development. Each of the more than 90 members of the forkhead family contains a conserved DNA binding ...

A number of proteins accumulate in the anaphase spindle midzone, but the interaction and precise role of these proteins in midzone organization remain obscure. Here, we found that the ...

image image N‐linked glycosylation of the perforin C‐terminus inhibits oligomerisation of perforin monomers, protecting the host cell from premature pore formation. Removal of this glycan in secretory ...