Integrating spatial transcriptomics, pseudotime, and machine learning analyses is effective for identifying prostate cancer biomarkers that are reliable in different settings and measurable with ...

AbstractBackground:. Type 2 diabetes mellitus (T2DM) has been associated with an increased risk of developing several common cancers, but it is unclear whether this association is causal. We aimed to ...

Radioligand therapy using an antibody targeting KRAS-derived, sotorasib-modified MHC I complexes elicits antitumor effects superior to those of sotorasib alone and provides a potential strategy to ...

PLCB1 functions as an oncogenic driver in cholangiocarcinoma development that confers an actionable therapeutic vulnerability to AKT inhibition.

A longitudinal clinical study using intraoperative 13C-glucose infusions in patients with non–small cell lung cancer finds that use of glucose by tumors to supply the tricarboxylic acid cycle predicts ...

A novel small-molecule drug, BI-3406, was used to block interactions between KRAS and the guanine exchange factor SOS1, hindering GTP binding by KRAS and thus reducing its activity to prevent tumor ...

We proved that anlotinib facilitates tumor vessel normalization at least partially through CD4 + T cells, reprograms the immunosuppressive TME into an immunostimulatory TME, significantly inhibits ...

Abstract. Background: Although incidence rates of breast cancer molecular subtypes are well documented, effects of molecular subtypes on breast cancer–specific survival using the largest population ...

In the U.S., incidence rates of some cancers have increased in 15- to 49-year-olds with concomitant increases in older age groups, suggesting that changes in risk factor prevalence and/or improvements ...

Surface IL1RAP maintains cyst(e)ine and glutathione pools to block anoikis and facilitate metastatic dissemination in Ewing sarcoma, and minimal expression in normal tissues nominates IL1RAP as a ...

Mutations in the KRAS oncogene are found in more than 90% of patients with pancreatic ductal adenocarcinoma (PDAC), with Gly-to-Asp mutations (KRAS G12D) being the most common. Here, we tested the ...

We evaluate cancer-protective effects of walnuts via formation of microbe-derived urolithin A, substantiating their functional benefits on serum inflammatory markers and immunologic composition of ...