Integrating spatial transcriptomics, pseudotime, and machine learning analyses is effective for identifying prostate cancer biomarkers that are reliable in different settings and measurable with ...

In this study, the fibronectin–ILT3 interaction is shown to represent a “stromal checkpoint” through which the extracellular matrix actively suppresses tumor-associated myeloid cells. Therapeutics ...

AbstractPurpose:. This research investigates the association between benzodiazepines (BZD) and cancer patient survival outcomes, the pancreatic cancer tumor microenvironment, and cancer-associated ...

Synthetic lethality and mass spectrometry were used to identify novel metabolic vulnerabilities in cancers with IDH1, but not IDH2, mutations that are targetable in the setting of ivosidenib ...

PLCB1 functions as an oncogenic driver in cholangiocarcinoma development that confers an actionable therapeutic vulnerability to AKT inhibition.

Surface IL1RAP maintains cyst(e)ine and glutathione pools to block anoikis and facilitate metastatic dissemination in Ewing sarcoma, and minimal expression in normal tissues nominates IL1RAP as a ...

Zongertinib, a covalent HER2 inhibitor, is active in HER2-driven preclinical models and patients and effectively targets HER2 oncogenic signaling while sparing wild-type EGFR, resulting in potent ...

The preclinical profile of STX-478, a mutant-selective, allosteric PI3Kα inhibitor, demonstrates its potential to expand the limited therapeutic window of approved inhibitors and significantly improve ...

GEN1046, which combines simultaneous PD-1/PD-L1 blockade and conditional 4-1BB stimulation, shows encouraging preclinical results and in a first-in-human dose-escalation study, demonstrates manageable ...

AbstractTrophoblast cell surface antigen 2 (TROP2) is highly expressed on various epithelial tumors and correlates with poor prognosis. We developed the novel TROP2-directed antibody–drug conjugate ...

Sotorasib and other selected KRASG12C inhibitors leverage differential dependence on switch-II pocket binding at amino acid position 95 to target all RASG12C isoforms, which has critical implications ...

AbstractCancer cells adapt and survive through the acquisition and selection of molecular modifications. This process defines cancer evolution. Building on a theoretical framework based on heritable ...