Background At least 60% of stroke, 40% of dementia and 35% of late-life depression (LLD) are attributable to modifiable risk ...

Background Many common neurological disorders are associated with advancing chronological age, but their association with biological age (BA) remains poorly understood. Methods We studied 325 870 ...

Background Previous natural history studies highlighted a consistent heterogeneity of disability trajectories among ...

Adult-onset leukodystrophies and genetic leukoencephalopathies comprise a diverse group of neurodegenerative disorders of white matter with a wide age of onset and phenotypic spectrum. Patients with ...

Objective: Parkinson’s disease (PD) is a progressive neurological disorder characterised by a large number of motor and non-motor features that can impact on function to a variable degree. This review ...

A systematic review and meta-analysis were conducted to quantify the efficacy of transcranial magnetic stimulation (TMS) and electroconvulsive therapy (ECT) for the treatment of motor dysfunction in ...

Correspondence to Dr Ruth Ann Marrie, Internal Medicine, University of Manitoba College of Medicine, Winnipeg, MB R3A 1R9, Canada; rmarrie{at}hsc.mb.ca Pain can be one of the worst symptoms of ...

Correspondence to Professor Yong-Ping Chen, Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, China; Yongping.chen{at}wchscu.cn Background Alzheimer’s disease (AD) is ...

Correspondence to Professor Jan D Lünemann, Department of Neurology with Institute of Translational Neurology, University Hospital Münster and Univerisity of Münster, Faculty of Medicine, Munster, ...

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder affecting the upper and lower motor neurons. A key clinical feature of ALS is the absence of accurate, early-stage ...

Dr J Mani, Department of Neurology, Ward 10, KEM Hospital, Parel Mumbai 400012, India. If you wish to reuse any or all of this article please use the link below which ...

Apathy is increasingly recognised as a common behavioural syndrome in psychiatric disorders, but it is conceptually ill defined. The aim of this study was to examine the concept of apathy as it is ...