In this study, the fibronectin–ILT3 interaction is shown to represent a “stromal checkpoint” through which the extracellular matrix actively suppresses tumor-associated myeloid cells. Therapeutics ...

Comparing scRNA-seq data of >1 million cells from 318 patients to a reference atlas of >260K normal human bone marrow cells revealed diverse ways in which differentiation can be disrupted in AML.

AbstractPurpose:. Posttreatment detection of ctDNA is strongly predictive of recurrence. Most minimal/molecular residual disease assays require prior tissue testing to guide ctDNA analysis, resulting ...

BBO-8520, a dual inhibitor of KRASG12C in its GTP- and GDP-bound states, has a novel mechanism of action that enables effector blockade and optimal target coverage, even in growth factor activated ...

AbstractPurpose:. Patients with melanoma progressing on immune checkpoint blockade may benefit from adoptive transfer of tumor-infiltrating lymphocytes (TIL).Patients and Methods:. We investigated the ...

The FDA approved yttrium-90 resin microspheres (SIR-Spheres Y-90; Sirtex Medical), also known as radioembolization or selective internal radiation therapy, for inoperable hepatocellular carcinoma. The ...

Abstract. Purpose: The phase II MONARCH 1 study was designed to evaluate the single-agent activity and adverse event (AE) profile of abemaciclib, a selective inhibitor of CDK4 and CDK6, in women with ...

In 1775, English surgeon Percivall Pott discovered that exposure to soot in chimneys caused scrotal cancer in chimney sweeps, the first time an agent found in the workplace was directly connected to ...

AbstractPurpose:. Pelareorep (Pel) is a type 3 oncolytic reovirus that upregulates PD-L1 expression. We determined the objective response rate (ORR) with paclitaxel (Pac), Pac + Pel, or Pac + Pel + ...

Abstract. The integration of artificial intelligence (AI) in cancer research has significantly advanced radiology, pathology, and multimodal approaches, offering unprecedented capabilities in image ...

Abstract. The Hippo pathway, a critical cell proliferation regulator, remains an underexplored oncogenic pathway in precision oncology. It is executed through YAP1/TAZ co-activators and the TEAD ...

Abstract. Radiomics, the extraction of quantitative data from images, holds promise for noninvasively characterizing tumor phenotypes. Tools like LIFEx have improved the accessibility, transparency, ...