Clinical research and clinical care share many similar risks. Both involve analogous procedures, many of which are invasive, and both use pharmacological agents with known and unknown toxicities.

Antibiotic overuse contributes to the growing threat of antimicrobial resistance (AMR). Despite local, national and global initiatives to target the problem, reducing overuse is challenging. Levels of ...

Background Despite significant advances, patient safety remains a critical public health concern. Daily huddles—discussions to identify and respond to safety risks—have been credited with enhancing ...

To achieve continuous quality improvement “it is not enough to do your best …” Continuous improvement in health care and elsewhere is not a contentious issue—but the means by which this may be ...

Patient safety management within healthcare systems globally can feel like a relentlessly negative treadmill. Mortality reviews, incident reporting systems and audits all focus attention on what goes ...

Introduction Medical training does not necessarily prepare graduates for the real world of healthcare in which continual improvement is required. Doctors in postgraduate training (DrPGT) rarely have ...

Background Pulmonary embolism (PE) is a potentially deadly disease and a diagnostic challenge in emergency departments (EDs). Established strategies exist for risk stratification and test stewardship ...

Objectives To provide national estimates of the number and clinical and economic burden of medication errors in the National Health Service (NHS) in England. Methods We used UK-based prevalence of ...

In medicine, artificial intelligence (AI) research is becoming increasingly focused on applying machine learning (ML) techniques to complex problems, and so allowing computers to make predictions from ...

Background Quality improvement collaboratives (QIC) have proliferated internationally, but there is little empirical evidence for their effectiveness. Method We searched Medline, Embase, CINAHL, ...

In the wake of adverse events, injured patients and their families have a complex range of needs and wants. The tort system, even when operating at its best, will inevitably fall far short of ...

Background Realising the full potential of the WHO Surgical Safety Checklist (SSC) to reduce perioperative harm requires the constructive engagement of all operating room (OR) team members during its ...